The Yankees are definitely going to the post-season, and the Blue Jays - barring the most tragic homestand in franchise history - will be there as well.
The Jays will be making just their third visit to PNC Park in Pittsburgh. They lost two of three in 2014, when the Pirates were pretty good. They lost two of three in 2008, when the Pirates were pretty awful. I have my own reasons for worrying about the 2022 Pirates. But later for that.